Pyrrolidine → 2,2,2-Trifluoro-1-[4-(4-methanesulfonyl-phenyl)-2-methyl-6-pyrrolidin-1-yl-quinolin-3-yl]-ethanone

반응식

[Br:1][c:2]1[cH:3][c:4]2[c:5](-[c:19]3[cH:20][cH:21][c:22]([S:25](=[O:26])(=[O:27])[CH3:28])[cH:23][cH:24]3)[c:6]([C:13]([C:14]([F:15])([F:16])[F:17])=[O:18])[c:7]([CH3:12])[n:8][c:9]2[cH:10][cH:11]1.[CH2:29]1[CH2:30][CH2:31][NH:32][CH2:33]1>>[c:2]1([N:32]2[CH2:31][CH2:30][CH2:29][CH2:33]2)[cH:3][c:4]2[c:5](-[c:19]3[cH:20][cH:21][c:22]([S:25](=[O:26])(=[O:27])[CH3:28])[cH:23][cH:24]3)[c:6]([C:13]([C:14]([F:15])([F:16])[F:17])=[O:18])[c:7]([CH3:12])[n:8][c:9]2[cH:10][cH:11]1

참가 물질

반응물 2

HCID 31268Pyrrolidine

HCID 115400851-[6-Bromo-4-(4-methanesulfonyl-phenyl)-2-methyl-quinolin-3-yl]-2,2,2-trifluoro-ethanone

생성물 1

HCID 115834852,2,2-Trifluoro-1-[4-(4-methanesulfonyl-phenyl)-2-methyl-6-pyrrolidin-1-yl-quinolin-3-yl]-ethanone

출처 및 근거

ORD 기록: ord-fd2539ee4ad147e289d0c472f8390c30
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (7/10)
DOI: 10.1039/C8SC04228D

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