Ammonia → 2-(Carbamoylamino)thiophene-3-carboxamide
반응식
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].ClC(Cl)(Cl)[C:12]([N:14]=C=O)=[O:13].N>C(#N)C.CO>[NH2:14][C:12]([NH:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8])=[O:13]참가 물질
6
실험 절차
2-Amino-3-thiophencarboxamide (0.44 g) was suspended in acetonitrile (25 ml) and trichloroacetylisocyanate (0.2 ml) added dropwise with stirring over 10 minutes. Stirring was continued for a further 3 h at room temperature and then a solution of ammonia in methanol (10 ml of a 2M solution) was added and stirring was continued for a further 2 h. The solvent was evaporated and the residue treated with water. The resultant solid was filtered off and washed with more water. Trituration with ether gave the title urea (0.2 g).
후처리
- stirringStirring
- waitwas continued for a further 3 h at room temperature
- stirringstirring
- waitwas continued for a further 2 h
- customThe solvent was evaporated
- additionthe residue treated with water
- filtrationThe resultant solid was filtered off
- washwashed with more water
출처 및 근거
- ORD 기록
- ord-f0c8411110a14024be0381e63896f360
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07098240B2
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