Ammonia → 2-(Carbamoylamino)thiophene-3-carboxamide

HRID 11421

반응식

HRID 11421 반응식
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].ClC(Cl)(Cl)[C:12]([N:14]=C=O)=[O:13].N>C(#N)C.CO>[NH2:14][C:12]([NH:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8])=[O:13]

참가 물질

6

반응물 3

HCID 222AmmoniaHCID 76400Trichloroacetyl isocyanateHCID 6994952-Aminothiophene-3-carboxamide

생성물 1

HCID 111714022-(Carbamoylamino)thiophene-3-carboxamide

시약·촉매·용매 2

HCID 887Methanol용매HCID 6342Acetonitrile용매

실험 절차

2-Amino-3-thiophencarboxamide (0.44 g) was suspended in acetonitrile (25 ml) and trichloroacetylisocyanate (0.2 ml) added dropwise with stirring over 10 minutes. Stirring was continued for a further 3 h at room temperature and then a solution of ammonia in methanol (10 ml of a 2M solution) was added and stirring was continued for a further 2 h. The solvent was evaporated and the residue treated with water. The resultant solid was filtered off and washed with more water. Trituration with ether gave the title urea (0.2 g).

후처리

  1. stirringStirring
  2. waitwas continued for a further 3 h at room temperature
  3. stirringstirring
  4. waitwas continued for a further 2 h
  5. customThe solvent was evaporated
  6. additionthe residue treated with water
  7. filtrationThe resultant solid was filtered off
  8. washwashed with more water

출처 및 근거

ORD 기록
ord-f0c8411110a14024be0381e63896f360
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07098240B2

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