Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 11423생성일: 2026년 10월 25일
Ammonia → 2-[(Aminocarbonyl)amino]-4-methyl-5-(1,4-benzodioxan-6-yl)-3-thiophenecarboxamide
https://huagongshe.com/reaction/11423
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Trichloroacetyl isocyanate | HCID 76400 | — |
| 반응물 | 2-Amino-4-methyl-5-(1,4-benzodioxan-6-yl)-3-thiophencarboxamide | HCID 21975867 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-[(Aminocarbonyl)amino]-4-methyl-5-(1,4-benzodioxan-6-yl)-3-thiophenecarboxamide | HCID 9880727 | — |
반응 단계
2-Amino-4-methyl-5-(1,4-benzodioxan-6-yl)-3-thiophencarboxamide (0.44 g) was dissolved in tetrahydrofuran (10 ml), cooled to 0° C. and trichloroacetylisocyanate (0.11 ml) added dropwise with stirring. Stirring was continued for a further 30 minutes at room temperature and then a solution of ammonia in methanol (8 ml of a 10% solution) was added and stirring was continued for a further 3 h. The solvent was evaporated and the residue treated with ethyl acetate and the product filtered off.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07098240B2 |
|---|
| 출처 데이터셋 | uspto-grants-2006_08 |
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| ORD ID | ord-0e662e7479ec46efaff48fad19e2d336 |
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| 출처 메모 | uspto-grants-2006_08 |
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