反应详情

温度

0 °C

2-Amino-4-methyl-5-(1,4-benzodioxan-6-yl)-3-thiophencarboxamide (0.44 g) was dissolved in tetrahydrofuran (10 ml), cooled to 0° C. and trichloroacetylisocyanate (0.11 ml) added dropwise with stirring. Stirring was continued for a further 30 minutes at room temperature and then a solution of ammonia in methanol (8 ml of a 10% solution) was added and stirring was continued for a further 3 h. The solvent was evaporated and the residue treated with ethyl acetate and the product filtered off.

1. stirringStirring
2. stirringstirring
3. waitwas continued for a further 3 h
4. customThe solvent was evaporated
5. additionthe residue treated with ethyl acetate
6. filtrationthe product filtered off