4-Chlorophenylacetyl chloride → 2-amino-7-(p-chlorophenylacetyl)-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine

HRID 1153762노트

반응식

HRID 1153762 반응식
Br.Br.[NH2:3][C:4]1[CH:5]=[N:6][C:7]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9][C:8]=2[N:14]=1.[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][C:23](Cl)=[O:24])=[CH:18][CH:17]=1>[OH-].O1CCOCC1>[NH2:3][C:4]1[CH:5]=[N:6][C:7]2[CH2:13][CH2:12][N:11]([C:23](=[O:24])[CH2:22][C:19]3[CH:20]=[CH:21][C:16]([Cl:15])=[CH:17][CH:18]=3)[CH2:10][CH2:9][C:8]=2[N:14]=1

참가 물질

5

반응물 2

HCID 906924-Chlorophenylacetyl chlorideHCID 204363772-amino-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine dihydrobromide

생성물 1

HCID 204364612-amino-7-(p-chlorophenylacetyl)-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine

시약·촉매·용매 2

HCID 961Hydroxide용매HCID 312751,4-Dioxane용매

실험 절차

5.8 gm (17.9 mmols) of 2-amino-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine dihydrobromide were dissolved in 50 ml of 2N hydroxide, and the solution was admixed dropwise with an ice-cooled solution of 7.5 gm of p-chlorophenyl-acetyl chloride in 50 ml of dioxane. The resulting mixture was stirred overnight and then evaporated, and the residue was extracted with chloroform. The chloroform extract was dried and then evaporated, and the residue was triturated with carbon tetrachloride and suction-filtered.

후처리

  1. customevaporated
  2. extractionthe residue was extracted with chloroform
  3. extractionThe chloroform extract
  4. customwas dried
  5. customevaporated
  6. customthe residue was triturated with carbon tetrachloride
  7. filtrationsuction-filtered

출처 및 근거

ORD 기록
ord-85652589ab6c4f1fa946c4b4a69f3106
출처 데이터셋
uspto-grants-1984_12
특허 번호
US04486433

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