Benzene → HCID 70467484, 화합물

HRID 1153878노트

반응식

HRID 1153878 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[CH:6]=O.C([CH:16](C([NH:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25]C=1)=O)[C:17]([OH:19])=[O:18])(O)=O.[NH:29]1[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]1.[OH2:35].[CH:36]1[CH:41]=CC=CC=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[CH:6]=[CH:41][C:36]([NH:29][C:34]1[C:16](=[CH:30][CH:31]=[CH:32][CH:33]=1)[C:17]([O-:19])=[O:18])=[O:35].[NH2+:22]1[CH2:23][CH2:28][CH2:27][CH2:26][CH2:25]1

참가 물질

6

반응물 5

HCID 241BenzeneHCID 962WaterHCID 8082PiperidineHCID 8419VeratraldehydeHCID 20222317HCID 20222317, 화합물

생성물 1

HCID 70467484HCID 70467484, 화합물수율 95.8%

실험 절차

A solution of 8.4 g of 3,4-dimethoxybenzaldehyde, 11.4 g of 2-carboxymalonanilic acid, and 4.3 g of piperidine in 50 ml of benzene is heated under reflux for 3 hours with the removal of water as formed during the reaction period. After the completion of the reaction, the reaction mixture is cooled and the precipitated crystals are collected by filtration and dried to obtain 19.7 g of piperidinium N-(3,4-dimethoxycinnamoyl)anthranilate (95.8% yield), m.p. 154°-156° C. The compound structure is confirmed by elemental analysis, and by IR and NMR spectroscopy.

후처리

  1. customas formed during the reaction period
  2. customAfter the completion of the reaction
  3. temperaturethe reaction mixture is cooled
  4. filtrationthe precipitated crystals are collected by filtration
  5. customdried

출처 및 근거

ORD 기록
ord-ad8de33b993d48b1808c78c9fc4e66c2
출처 데이터셋
uspto-grants-1984_12
특허 번호
US04486597

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