Phenyl Isothiocyanate → HCID 4244266, 화합물

HRID 1153968노트

반응식

HRID 1153968 반응식
[C:1]1([N:7]=[C:8]=[S:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:10][C:11]1[CH:23]=[CH:22][C:14]([CH2:15][NH:16][CH:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)=[CH:13][CH:12]=1>C1(C)C=CC=CC=1>[F:10][C:11]1[CH:12]=[CH:13][C:14]([CH2:15][N:16]([CH:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)[C:8]([NH:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[S:9])=[CH:22][CH:23]=1

참가 물질

4

반응물 2

HCID 7673Phenyl IsothiocyanateHCID 834084HCID 834084, 화합물

생성물 1

HCID 4244266HCID 4244266, 화합물수율 84%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

6.75 g (0.05 mol) of phenyl isothiocyanate were rapidly added dropwise to a solution of 9.65 g (0.05 mol) of N-4-fluorobenzyl-N-cyclopentylamine in 80 ml of toluene. The mixture was heated to the boil for 30 minutes, the solvent was distilled off in vacuo, and the residue was recrystallized from isopropanol. 13.8 g of N-4-fluorobenzyl-N-cyclopentyl-N'-phenylthiourea of melting point 135° C. were obtained.

후처리

  1. temperatureThe mixture was heated to the boil for 30 minutes
  2. distillationthe solvent was distilled off in vacuo
  3. customthe residue was recrystallized from isopropanol

출처 및 근거

ORD 기록
ord-0996041c7caf44249cfbd958caacc99b
출처 데이터셋
uspto-grants-1984_12
특허 번호
US04487783

반응 노트

불러오는 중…