HCID 20435989, 화합물 → HCID 20435943, 화합물

HRID 1154035노트

반응식

HRID 1154035 반응식
[CH3:1][C:2]1([CH2:17][CH2:18][O:19]C2CCCCO2)[C:14](=[O:15])[N:5]2[CH2:6][CH:7]=[CH:8][CH:9]([C:10]([O:12][CH3:13])=[O:11])[N:4]2[C:3]1=[O:16]>Cl.CO>[OH:19][CH2:18][CH2:17][C:2]1([CH3:1])[C:14](=[O:15])[N:5]2[CH2:6][CH:7]=[CH:8][CH:9]([C:10]([O:12][CH3:13])=[O:11])[N:4]2[C:3]1=[O:16]

참가 물질

4

반응물 1

HCID 20435989HCID 20435989, 화합물

생성물 1

HCID 20435943HCID 20435943, 화합물수율 97%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 887Methanol용매

실험 절차

A solution of 3.52 g (0.01 mol) of methyl 2,3,5,8-tetrahydro-2-methyl-1,3-dioxo-2[2-(tetrahydro-2-pyranyloxy)ethyl]-1H-pyrazolo[1,2-a]pyridazine-5-carboxylate in 50 ml of 1M hydrochloric acid and 50 ml of methanol was stirred at room temperature for 1.5 hours. The solvent was removed by evaporation in vacuo. The solid residue was taken up in dichloromethane, dried over magnesium sulfate and evaporated to give 2.6 g (97%) of methyl 2,3,5,8-tetrahydro-2-(2-hydroxyethyl)-2-methyl-1,3-dioxo-1H-pyrazolo[1,2-a]pyridazine-5-carboxylate having a melting point of 97°-99° C. (from diethyl ether).

후처리

  1. customThe solvent was removed by evaporation in vacuo
  2. dry with materialdried over magnesium sulfate
  3. customevaporated

출처 및 근거

ORD 기록
ord-4d5f6c5945fa446d9528c516b17a3c9e
출처 데이터셋
uspto-grants-1984_12
특허 번호
US04487929

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