참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | benzyloxycarbonyl-L-tryptophan | HCID 101176 | — |
| 반응물 | L-Proline 1,1-dimethylethyl ester | HCID 6453108 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Z-Trp-Pro-OBut | HCID 13178803 | — |
반응 단계
10.92 g (53 mmoles) of DCC are added at 0° C. to a solution of 16.9 g (50 mmoles) of Z-Trp-OH, 8.55 g (50 mmoles) of H-Pro-OBut and 6.75 g (50 mmoles) of HOBt in 75 ml of dimethylformamide. The mixture is stirred for 2 hours at 0° C. and left to stand overnight at room temperature. The precipitate is filtered off and the filtrate is concentrated. The residue is worked up analogously to Example 1 a. The residue is triturated with ether. Yield 19.49 g (79%), melting point 173°, [α]D25 =-54.2° (c=1, dimethylformamide).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04487764 |
|---|
| 출처 데이터셋 | uspto-grants-1984_12 |
|---|
| ORD ID | ord-d31d4dc102284d9abf1553600d7eff4d |
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| 출처 메모 | uspto-grants-1984_12 |
|---|
