反应详情

温度

0 °C

10.92 g (53 mmoles) of DCC are added at 0° C. to a solution of 16.9 g (50 mmoles) of Z-Trp-OH, 8.55 g (50 mmoles) of H-Pro-OBut and 6.75 g (50 mmoles) of HOBt in 75 ml of dimethylformamide. The mixture is stirred for 2 hours at 0° C. and left to stand overnight at room temperature. The precipitate is filtered off and the filtrate is concentrated. The residue is worked up analogously to Example 1 a. The residue is triturated with ether. Yield 19.49 g (79%), melting point 173°, [α]D25 =-54.2° (c=1, dimethylformamide).

1. waitleft
2. waitto stand overnight at room temperature
3. filtrationThe precipitate is filtered off
4. concentrationthe filtrate is concentrated
5. customThe residue is triturated with ether
6. customYield 19.49 g (79%), melting point 173°, [α]D25 =-54.2° (c=1, dimethylformamide)