Sodium Hydroxide → N-[3-(4-phenyl-1H-imidazol-1-yl)propyl]-2-furanecarboxamide

HRID 1154335노트

반응식

HRID 1154335 반응식
[C:1]1([C:7]2[N:8]=[CH:9][N:10]([CH2:12][CH2:13][CH2:14][NH2:15])[CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+].[O:18]1[CH:22]=[CH:21][CH:20]=[C:19]1[C:23](Cl)=[O:24]>C(Cl)Cl>[C:1]1([C:7]2[N:8]=[CH:9][N:10]([CH2:12][CH2:13][CH2:14][NH:15][C:23]([C:19]3[O:18][CH:22]=[CH:21][CH:20]=3)=[O:24])[CH:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 682422-Furancarbonyl chlorideHCID 135889123-(4-Phenyl-1H-imidazol-1-yl)propan-1-amine

생성물 1

HCID 13371090N-[3-(4-phenyl-1H-imidazol-1-yl)propyl]-2-furanecarboxamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A mixture of 2.0 g. of 4-phenyl-1H-imidazole-1-propanamine, 50 ml. of methylenechloride and 10 ml. of 1N sodium hydroxide was stirred and 2.0 ml. of 2-furoyl chloride was added. The mixture was stirred for eighteen hours, methylene chloride was added and the layers were separated. The organic layer was washed with water, dried over magnesium sulfate and concentrated. The residue was washed onto a filter with diethyl ether, giving the desired product, m.p. 120°-122° C.

후처리

  1. additionA mixture of 2.0 g
  2. customthe layers were separated
  3. washThe organic layer was washed with water
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated
  6. washThe residue was washed onto
  7. filtrationa filter with diethyl ether

출처 및 근거

ORD 기록
ord-3c253e52698e49da9182f65322d084c1
출처 데이터셋
uspto-grants-1984_12
특허 번호
US04489089

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