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Hydrochloric Acid → 4-[[3-(p-Chlorophenyl)propyl]methylamino]benzoic acid

HRID 1154355
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HRID 1154355 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][N:11]([CH3:23])[C:12]2[CH:22]=[CH:21][C:15]([C:16]([O:18]CC)=[O:17])=[CH:14][CH:13]=2)=[CH:4][CH:3]=1.C(O)C.[OH-].[K+].Cl>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][CH2:10][N:11]([CH3:23])[C:12]2[CH:13]=[CH:14][C:15]([C:16]([OH:18])=[O:17])=[CH:21][CH:22]=2)=[CH:6][CH:7]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14797Potassium HydroxideHCID 442788874-[[3-(p-Chlorophenyl)propyl]methylamino]benzoic acid, ethyl ester

생성물 1

HCID 442788864-[[3-(p-Chlorophenyl)propyl]methylamino]benzoic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A 1.80 g. portion of 4-[[3-(p-chlorophenyl)propyl]methylamino]benzoic acid, ethyl ester is dissolved in 15 ml. of 95% ethanol. A 1 g. portion of potassium hydroxide is added, and the mixture is refluxed overnight. The solution is poured into 30 ml. of water, the pH is adjusted to 6 using 37% hydrochloric acid, and the solid is collected and dried. This solid is dissolved in benzene, filtered, and evaporated, giving 750 mg. of the desired product.

후처리

  1. temperaturethe mixture is refluxed overnight
  2. additionThe solution is poured into 30 ml
  3. customthe solid is collected
  4. customdried
  5. dissolutionThis solid is dissolved in benzene
  6. filtrationfiltered
  7. customevaporated
  8. customgiving 750 mg

출처 및 근거

ORD 기록
ord-88abf7045b4d488ab11c42876ca3fc58
출처 데이터셋
uspto-grants-1984_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04489094

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