홈 MCP 워크벤치 Skills

홈 워크벤치 알림 마이페이지

llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0

홈
반응

Hydrochloric Acid → 7-Amino-3-(benzothiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acid

HRID 1154807

인쇄 미리보기

반응식

HRID 1154807 반응식

CC(O[CH2:5][C:6]1[CH2:15][S:14][C@@H:9]2[C@H:10]([NH2:13])[C:11](=[O:12])[N:8]2[C:7]=1[C:16]([OH:18])=[O:17])=O.[SH:19][C:20]1[S:21][C:22]2[CH:28]=[CH:27][CH:26]=[CH:25][C:23]=2[N:24]=1.C(=O)(O)[O-].[Na+].Cl>O.CC(C)=O>[NH2:13][CH:10]1[C:11](=[O:12])[N:8]2[C:7]([C:16]([OH:18])=[O:17])=[C:6]([CH2:5][S:19][C:20]3[S:21][C:22]4[CH:28]=[CH:27][CH:26]=[CH:25][C:23]=4[N:24]=3)[CH2:15][S:14][C@H:9]12

참가 물질 실험 절차 후처리 출처 및 근거 반응 노트

참가 물질

7

반응물 4

HCID 313Hydrochloric Acid

HCID 4413287-Aminocephalosporanic acid

HCID 516892Sodium Bicarbonate

HCID 178418395HCID 178418395, 화합물

생성물 1

HCID 128210677-Amino-3-(benzothiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acid수율 58.1%

시약·촉매·용매 2

HCID 180

Acetone

용매

HCID 962Water용매

실험 절차

To a mixture of 7-aminocephalosporanic acid (23.1 g., purity 86.4%) and 2-mercaptobenzothiazole (14.7 g.) in water (800 ml.), sodium bicarbonate (13.5 g.) was added portionwise with stirring, and acetone (250 ml.) was added thereto. The mixture was stirred at 73° C. for 4.5 hours, cooled below 20° C. and adjusted to pH 3.4 with 6 N hydrochloric acid. The precipitating crystals were collected by filtration, washed with water and acetone in turn and dried under reduced pressure to give 7-amino-3-(benzothiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acid (18.7 g.).

후처리

additionwas added portionwise
stirringThe mixture was stirred at 73° C. for 4.5 hours
temperaturecooled below 20° C.
filtrationThe precipitating crystals were collected by filtration
washwashed with water and acetone in turn
customdried under reduced pressure

출처 및 근거

ORD 기록: ord-c7930de793a341789fb2a42b0e6688e4
출처 데이터셋: uspto-grants-1981_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04298529

반응 노트

불러오는 중…

이 페이지에서참가 물질 실험 절차 후처리 출처 및 근거 반응 노트