Ammonia → 1H-Purine, 8-(2,4-dimethoxyphenyl)-

HRID 1155064

반응식

HRID 1155064 반응식
[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][N:5]=[CH:4][N:3]=1.[CH3:9][O:10][C:11]1[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][C:12]=1[C:13](O)=O.N>>[CH3:9][O:10][C:11]1[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][C:12]=1[C:13]1[NH:8][C:7]2[C:2](=[N:3][CH:4]=[N:5][CH:6]=2)[N:1]=1

참가 물질

4

반응물 3

HCID 222AmmoniaHCID 70522,4-Dimethoxybenzoic acidHCID 837034,5-Diaminopyrimidine

생성물 1

HCID 30599121H-Purine, 8-(2,4-dimethoxyphenyl)-

실험 절차

A mixture of 5.5 g of 4,5-diaminopyrimidine and 10.9 g of 2,4-dimethoxy-benzoic acid was triturated in a mortar. The mixture was added to 100 ml of phosphorus oxychloride and refluxed for one hour. The phosphorus oxychloride was decomposed under stirring into water, and the solution obtained was neutralized with ammonia after filtration. The precipitated product was recrystallized from water and ethanol/cyclohexane (volume ratio of 1:3).

후처리

  1. customwas triturated in a mortar
  2. additionThe mixture was added to 100 ml of phosphorus oxychloride
  3. temperaturerefluxed for one hour
  4. customthe solution obtained
  5. filtrationafter filtration
  6. customThe precipitated product was recrystallized from water and ethanol/cyclohexane (volume ratio of 1:3)

출처 및 근거

ORD 기록
ord-6a90d463b66a4dcfa829660cb11e8926
출처 데이터셋
uspto-grants-1981_11
특허 번호
US04299834

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