Pyridine, 2-(4-methoxyphenoxy)-5-(trifluoromethyl)- → 4-(5-Trifluoromethyl-pyridin-2-yloxy)-phenol

HRID 1155474

반응식

HRID 1155474 반응식
C[O:2][C:3]1[CH:19]=[CH:18][C:6]([O:7][C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][N:9]=2)=[CH:5][CH:4]=1.Cl.N1C=CC=CC=1>O.Cl>[OH:2][C:3]1[CH:19]=[CH:18][C:6]([O:7][C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:15])[F:16])=[CH:10][N:9]=2)=[CH:5][CH:4]=1

참가 물질

5

반응물 2

HCID 155242Pyridine, 2-(4-methoxyphenoxy)-5-(trifluoromethyl)-HCID 10176127Pyridinium chloride

생성물 1

HCID 1552414-(5-Trifluoromethyl-pyridin-2-yloxy)-phenol

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 962Water용매

실험 절차

The product from (c) (1.7 g) and excess of pyridine hydrochloride were heated together for 8 hours at 180° C. The mixture was cooled, diluted with water and 2-molar hydrochloric acid, and extracted with ether. The extracts were dried and evaporated to yield an oil identified as the required hydroxy compound.

후처리

  1. temperatureThe mixture was cooled
  2. extractionextracted with ether
  3. customThe extracts were dried
  4. customevaporated
  5. customto yield an oil

출처 및 근거

ORD 기록
ord-b2b93f581afd4ba08de951bf7d3c848f
출처 데이터셋
uspto-grants-1981_11
특허 번호
US04302242

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