Mescaline → 2-Formyl-3,4,5-trimethoxy-phenylethylamine

HRID 1155502

반응식

HRID 1155502 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:13][CH2:14][NH2:15])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[C:16](OC(=O)C)(=[O:18])C>C(O)=O>[CH:16]([CH:13]([C:5]1[CH:6]=[C:7]([O:11][CH3:12])[C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=1)[CH2:14][NH2:15])=[O:18]

참가 물질

4

반응물 2

HCID 4076MescalineHCID 7918Acetic Anhydride

생성물 1

HCID 867381162-Formyl-3,4,5-trimethoxy-phenylethylamine

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

1.422 kg of 3,4,5-trimethoxy-phenylethylamine is slowly added to a mixture of 2.185 kg of 98% formic acid and 1.728 kg of acetic anhydride, while maintaining the temperature at about 50°. The reaction bath is maintained at this temperature for about 3 hours and the formic acid and acetic acid mixture and the excess anhydride is distilled. The formylated derivative thus obtained (1.734 kg) is used unpurified.

후처리

  1. temperaturewhile maintaining the temperature at about 50°
  2. temperatureThe reaction bath is maintained at this temperature for about 3 hours
  3. distillationthe formic acid and acetic acid mixture and the excess anhydride is distilled
  4. customThe formylated derivative thus obtained (1.734 kg)

출처 및 근거

ORD 기록
ord-19c0d8cc26114b74b636f14f770ebde7
출처 데이터셋
uspto-grants-1981_11
특허 번호
US04302458

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