m-Chloroperbenzoic acid → HCID 20561000, 화합물

HRID 1155522노트

반응식

HRID 1155522 반응식
ClC1C=C(C=CC=1)C(OO)=[O:6].[Cl:12][C:13]1[CH:22]=[C:21]2[C:16]([C:17](=[O:27])[C:18]([S:24]([CH3:26])=[O:25])=[CH:19][N:20]2[CH3:23])=[CH:15][CH:14]=1>C(Cl)(Cl)Cl>[Cl:12][C:13]1[CH:22]=[C:21]2[C:16]([C:17](=[O:27])[C:18]([S:24]([CH3:26])(=[O:6])=[O:25])=[CH:19][N:20]2[CH3:23])=[CH:15][CH:14]=1

참가 물질

4

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 202591227-Chloro-1-methyl-3-(methylsulfinyl)-4(1H)-quinolinone

생성물 1

HCID 20561000HCID 20561000, 화합물

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

A solution of 3-chloroperoxybenzoic acid (85%, 6.75 g.) in chloroform (70 ml.) was added dropwise to a stirred solution of 7-chloro-1-methyl-3-methylsulphinyl-4-quinolone (6.25 g.) in chloroform (150 ml.). The resulting solution was stirred at room temperature for 2 hours and then washed repeatedly with saturated aqueous sodium carbonate solution to remove peroxide. The resulting solution was dried over anhydrous magnesium sulphate and then evaporated. The solid residue was crystallised from ethanol using charcoal to give 7-chloro-1-methyl-3-methylsulphonyl-4-quinolone, m.p. 241°-242°.

후처리

  1. washwashed repeatedly with saturated aqueous sodium carbonate solution
  2. customto remove peroxide
  3. dry with materialThe resulting solution was dried over anhydrous magnesium sulphate
  4. customevaporated
  5. customThe solid residue was crystallised from ethanol

출처 및 근거

ORD 기록
ord-583592bfb1e041c3ab78cc346d5a5aef
출처 데이터셋
uspto-grants-1981_11
특허 번호
US04302460

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