Nitric Acid → Flutamide

HRID 1155579

반응식

HRID 1155579 반응식
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[C:5]([CH:12]=[CH:13][CH:14]=1)[NH:6][C:7](=[O:11])[CH:8]([CH3:10])[CH3:9].OS(O)(=O)=O.O=S(=O)=O.[N+:26]([O-])([OH:28])=[O:27]>O>[F:1][C:2]([F:15])([F:16])[C:3]1[CH:4]=[C:5]([CH:12]=[CH:13][C:14]=1[N+:26]([O-:28])=[O:27])[NH:6][C:7](=[O:11])[CH:8]([CH3:10])[CH3:9]

참가 물질

5

반응물 3

HCID 944Nitric AcidHCID 24681Fuming sulfuric acidHCID 1372643-Trifluoromethylisobutyranilide

생성물 1

HCID 3397Flutamide

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
5 °C

실험 절차

Add portion-wise 57.5 g. of m-trifluoromethyl isobutyranilide to 260 ml. of 15-18% oleum while maintaining the internal temperature at about 5° C. To this mixture add drop-wise 20 g. of 90% nitric acid with stirring. Stir at about 5° C. for 2 hours and pour into about 11/2 liters of ice and water with stirring. Collect the 3'-trifluoromethyl-4'-nitro-isobutyranilide by filtration and wash with water until substantially free of excess acid.

후처리

  1. additionAdd portion-wise 57.5 g
  2. additionTo this mixture add drop-wise 20 g
  3. stirringwith stirring
  4. customCollect the 3'-trifluoromethyl-4'-nitro-isobutyranilide
  5. filtrationby filtration
  6. washwash with water until substantially free of excess acid

출처 및 근거

ORD 기록
ord-3bb1905416d647b5a51cf2e60bb04d16
출처 데이터셋
uspto-grants-1981_11
특허 번호
US04302599

연결된 노트

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