Piperidine, 1-methyl-4-(4-nitrophenoxy)-4-phenyl- → Piperidine, 4-(p-aminophenoxy)-1-methyl-4-phenyl-

HRID 1156028

반응식

HRID 1156028 반응식
[CH3:1][N:2]1[CH2:7][CH2:6][C:5]([O:14][C:15]2[CH:20]=[CH:19][C:18]([N+:21]([O-])=O)=[CH:17][CH:16]=2)([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:4][CH2:3]1>C(O)C.[Pt]>[NH2:21][C:18]1[CH:19]=[CH:20][C:15]([O:14][C:5]2([C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=3)[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH2:6]2)=[CH:16][CH:17]=1

참가 물질

4

반응물 1

HCID 3060390Piperidine, 1-methyl-4-(4-nitrophenoxy)-4-phenyl-

생성물 1

HCID 3060392Piperidine, 4-(p-aminophenoxy)-1-methyl-4-phenyl-수율 74.4%

시약·촉매·용매 2

HCID 23939Platinum촉매HCID 702Ethanol용매

실험 절차

51 g of 1-methyl-4-(4-nitrophenoxy)-4-phenylpiperidine are dissolved in 1.5 liters of ethanol and are hydrogenated under a hydrogen pressure of 1 atmosphere in the presence of platinum. The catalyst is filtered off, the filtrate is concentrated to 300 ml and crystals (which have separated out) are collected. 34.3 g of the title compound of m.p. 173° to 174° C. are obtained by successive concentration of the filtrate.

후처리

  1. filtrationThe catalyst is filtered off
  2. concentrationthe filtrate is concentrated to 300 ml and crystals (which
  3. customhave separated out)
  4. customare collected

출처 및 근거

ORD 기록
ord-8ad115a3f6d441419d4866e6503e5fc5
출처 데이터셋
uspto-grants-1982_06
특허 번호
US04333942

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