Palmitoyl chloride → Ethyl 3-fluoro-4-(hexadecanoylamino)benzoate

HRID 1156105노트

반응식

HRID 1156105 반응식
[C:1](Cl)(=[O:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[NH2:19][C:20]1[CH:30]=[CH:29][C:23]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:22][C:21]=1[F:31]>C(Cl)Cl>[F:31][C:21]1[CH:22]=[C:23]([CH:29]=[CH:30][C:20]=1[NH:19][C:1](=[O:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[C:24]([O:26][CH2:27][CH3:28])=[O:25]

참가 물질

4

반응물 2

HCID 8206Palmitoyl chlorideHCID 20536493Ethyl 4-Amino-3-fluorobenzoate

생성물 1

HCID 20536492Ethyl 3-fluoro-4-(hexadecanoylamino)benzoate

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution of hexadecanoyl chloride (20 g) in 100 ml of methylene chloride is slowly added with stirring to a solution of 20 g of ethyl 4-amino-3-fluorobenzoate in 100 ml of methylene chloride. The mixture is filtered and the filtrate is washed with dilute hydrochloric acid and water, dried and the solvent evaporated. Crystallization of the residue from acetonitrile affords ethyl 3-fluoro-4-(hexadecanoylamino)benzoate.

후처리

  1. filtrationThe mixture is filtered
  2. washthe filtrate is washed with dilute hydrochloric acid and water
  3. customdried
  4. customthe solvent evaporated
  5. customCrystallization of the residue from acetonitrile

출처 및 근거

ORD 기록
ord-bf29e2917c8a4844beaabe6d3283011f
출처 데이터셋
uspto-grants-1982_06
특허 번호
US04333940

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