2-(4-Chlorophenoxy)-5-nitropyridine → 6-(4-Chlorophenoxy)pyridin-3-amine

HRID 1156210노트

반응식

HRID 1156210 반응식
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][N:8]=2)=[CH:4][CH:3]=1.[H][H]>O1CCCC1.C(OCC)(=O)C.[Pt](=O)=O>[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9][N:8]=2)=[CH:4][CH:3]=1

참가 물질

6

반응물 2

HCID 2771852-(4-Chlorophenoxy)-5-nitropyridineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 4206446-(4-Chlorophenoxy)pyridin-3-amine수율 94.2%

시약·촉매·용매 3

HCID 345198Adams' catalyst촉매HCID 8028Tetrahydrofuran용매HCID 8857Ethyl Acetate용매

실험 절차

4-Chlorophenoxy-5-nitropyridine (19.9 g) and platinum dioxide (0.1 g) were suspended in a mixture of tetrahydrofuran (100 ml) and ethyl acetate (50 ml), and catalytic reduction was carried out until 5.0 liters of hydrogen were absorbed. After removal of the catalyst by filtration, the solvent was distilled out under reduced pressure. The precipitated crystals were washed with a small amount of ether to give 16.5 g of 4-chlorophenoxy-5-aminopyridine as white crystals. M.P., 87°-88° C.

후처리

  1. customwere absorbed
  2. customAfter removal of the catalyst
  3. filtrationby filtration
  4. distillationthe solvent was distilled out under reduced pressure
  5. washThe precipitated crystals were washed with a small amount of ether

출처 및 근거

ORD 기록
ord-17fe63a8741e42b2941a15393552ca86
출처 데이터셋
uspto-grants-1982_06
특허 번호
US04334912

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