Water → N-(1-cyano-1,2-dimethylpropyl)-2,3-Dibromopropionamide

HRID 1156230

반응식

HRID 1156230 반응식
Cl.[CH3:2][C:3]([NH2:9])([CH:6]([CH3:8])[CH3:7])[C:4]#[N:5].[OH-].[Na+].O.[Br:13][CH:14]([CH2:18][Br:19])[C:15](Cl)=[O:16]>ClCCl>[C:4]([C:3]([NH:9][C:15](=[O:16])[CH:14]([Br:13])[CH2:18][Br:19])([CH3:2])[CH:6]([CH3:8])[CH3:7])#[N:5]

참가 물질

6

반응물 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 867902,3-Dibromopropanoyl chlorideHCID 12945444HCID 12945444, 화합물

생성물 1

HCID 12945446N-(1-cyano-1,2-dimethylpropyl)-2,3-Dibromopropionamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A mixture of 4.5 g (0.03 mole) of the 2,3-dimethyl-2-aminobutyronitrile hydrochloride, 4.8 g (0.06 mole) of 50% aqueous sodium hydroxide, 15 ml of dichloromethane and 15 ml of water was prepared. A second solution of 7.5 g (0.03 mole) of 2,3-dibromopropionyl chloride in 15 ml dichloromethane was added with rapid stirring to the first mixture at 10°-15° C. The mixture was then allowed to reach room temperature.

후처리

  1. customwas prepared
  2. customto reach room temperature

출처 및 근거

ORD 기록
ord-ba09355c1cf44c339cc5a238e027a803
출처 데이터셋
uspto-grants-1982_06
특허 번호
US04335053

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