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Glycidol → HCID 12855751, 화합물

HRID 1156520
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반응식

HRID 1156520 반응식
[CH3:1][C:2]([NH2:12])([CH3:11])[CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[CH2:13]1[O:15][CH:14]1[CH2:16][OH:17]>CC(O)C>[CH3:11][C:2]([NH:12][CH2:13][CH:14]([OH:15])[CH2:16][OH:17])([CH3:1])[CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 11164GlycidolHCID 12851223HCID 12851223, 화합물

생성물 1

HCID 12855751HCID 12855751, 화합물

시약·촉매·용매 1

HCID 3776Isopropanol용매2회

반응 조건

온도
75 °C

실험 절차

To 1,1-dimethyl-3-phenylpropylamine (3.6 g., 22 mmole) in 20 ml. 2-propanol at 50° C. in an oil bath was added glycidol (1.7 g., 23 mmole) in 10 ml. 2-propanol dropwise over 5-10 min. The mixture was heated at 75° C. for 2 hours. After evaporation of the solvent, vacuum distillation provided 3.9 g. (75%) of 3-(1,1-dimethyl-3-phenylpropylamino)-1,2-dihydroxypropane (bp 160°-180°/0.5 mm which crystallized upon standing (mp 74°-77° C.).

후처리

  1. customAfter evaporation of the solvent, vacuum distillation
  2. customprovided 3.9 g
  3. custom(75%) of 3-(1,1-dimethyl-3-phenylpropylamino)-1,2-dihydroxypropane (bp 160°-180°/0.5 mm which crystallized

출처 및 근거

ORD 기록
ord-efee8ac98e8f436082c9ca37ad34aaee
출처 데이터셋
uspto-grants-1982_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04336261

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