Water → 2-Chloro-4-phenylthiazole-5-carboxylic acid

HRID 1156604노트

반응식

HRID 1156604 반응식
[Cl:1][C:2]1[S:3][C:4]([C:13]([O:15]CC)=[O:14])=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:6]=1.[OH-].[Na+].O>O1CCCC1>[Cl:1][C:2]1[S:3][C:4]([C:13]([OH:15])=[O:14])=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:6]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 13041816Ethyl 2-chloro-4-phenyl-1,3-thiazole-5-carboxylate

생성물 1

HCID 130418282-Chloro-4-phenylthiazole-5-carboxylic acid수율 90.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 53.4 g (0.2 mole) of ethyl 2-chloro-4-phenyl-5-thiazolecarboxylate, 8.0 g (0.2 mole) of NaOH, 200 ml. of water and 400 ml. of tetrahydrofuran was stirred for 16 hours and extracted with ether. The organic layer was discarded. The aqueous layer was made acidic and the precipitate was collected and air-dried to give 43.2 g (90%) of the desired product, m.p. 170°-171° C.

후처리

  1. extractionextracted with ether
  2. customthe precipitate was collected
  3. customair-dried

출처 및 근거

ORD 기록
ord-037f94191c814069bad2c02e159ffa2a
출처 데이터셋
uspto-grants-1982_06
특허 번호
US04336389

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