Sodium Hydroxide → sodium N-(3,4-dimethoxycinnamoyl)-4-chloroanthranilate

HRID 1156860

반응식

HRID 1156860 반응식
[OH-].[Na+:2].[CH3:3][O:4][C:5]1[CH:6]=[C:7]([CH:23]=[CH:24][C:25]=1[O:26][CH3:27])[CH:8]=[CH:9][C:10]([NH:12][C:13]1[C:14](=[CH:18][CH:19]=[C:20]([Cl:22])[CH:21]=1)[C:15]([OH:17])=[O:16])=[O:11]>>[CH3:3][O:4][C:5]1[CH:6]=[C:7]([CH:23]=[CH:24][C:25]=1[O:26][CH3:27])[CH:8]=[CH:9][C:10]([NH:12][C:13]1[C:14](=[CH:18][CH:19]=[C:20]([Cl:22])[CH:21]=1)[C:15]([O-:17])=[O:16])=[O:11].[Na+:2]

참가 물질

3

반응물 2

HCID 14798Sodium HydroxideHCID 54481802N-(3,4-dimethoxycinnamoyl)-4-chloroanthranilic acid

생성물 1

HCID 70541710sodium N-(3,4-dimethoxycinnamoyl)-4-chloroanthranilate수율 83.8%

실험 절차

In 300 ml of an aqueous alcoholic solution (ethanol 1:water 1) containing 0.4 g of sodium hydroxide is added 3.6 g of N-(3,4-dimethoxycinnamoyl)-4-chloroanthranilic acid and the mixture is warmed to be completely dissolved. The solution is concentrated under a reduced pressure, the residue is dissolved in 200 ml of warmed ethanol and to this solution is added 900 ml of ether. The precipitated crystals are collected by filtration and dried under reduced pressure to obtain 3.2 g of sodium N-(3,4-dimethoxycinnamoyl)-4-chloroanthranilate.

후처리

  1. temperaturethe mixture is warmed
  2. dissolutionto be completely dissolved
  3. concentrationThe solution is concentrated under a reduced pressure
  4. dissolutionthe residue is dissolved in 200 ml of warmed ethanol and to this solution
  5. additionis added 900 ml of ether
  6. filtrationThe precipitated crystals are collected by filtration
  7. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-72c10026ca324256b03cc1fe68edad40
출처 데이터셋
uspto-grants-1982_06
특허 번호
US04337270

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