Phosphorus oxide (P4O10) → 1-(4-Fluorophenyl)-5-methyl-3,4-dihydroisoquinoline

반응식

[F:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([NH:8][CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:17])=O)=[CH:4][CH:3]=1.P(Cl)(Cl)(Cl)=O.O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O>>[F:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]2[C:16]3[C:11](=[C:12]([CH3:17])[CH:13]=[CH:14][CH:15]=3)[CH2:10][CH2:9][N:8]=2)=[CH:4][CH:3]=1

참가 물질

반응물 3

HCID 14812Phosphorus oxide (P4O10)

HCID 24813Phosphorus oxychloride

HCID 128518101-(4-Fluorobenzoylamino)-2-(2-methylphenyl)ethane

생성물 1

HCID 128518221-(4-Fluorophenyl)-5-methyl-3,4-dihydroisoquinoline

실험 절차

1-(4-Fluorobenzoylamino)-2-(2-methylphenyl)-ethane, phosphorus oxychloride and phosphorus pentoxide were reacted in the same way as in step (b) of Example 1 to afford 1-(4-fluorophenyl)-5-methyl-3,4-dihydroisoquinoline as colorless prisms having a melting point of 71.0 to 71.5° C.

출처 및 근거

ORD 기록: ord-6fca38ba2e984a4a909cd344871a7f68
출처 데이터셋: uspto-grants-1982_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04337256

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