1-Isopropyl-5-dichloroacetylaminomethylisoquinoline → 1-Isopropyl-5-aminomethylisoquinoline

HRID 1156910노트

반응식

HRID 1156910 반응식
[CH:1]([C:4]1[C:13]2[C:8](=[C:9]([CH2:14][NH:15]C(=O)C(Cl)Cl)[CH:10]=[CH:11][CH:12]=2)[CH:7]=[CH:6][N:5]=1)([CH3:3])[CH3:2]>Cl>[CH:1]([C:4]1[C:13]2[C:8](=[C:9]([CH2:14][NH2:15])[CH:10]=[CH:11][CH:12]=2)[CH:7]=[CH:6][N:5]=1)([CH3:3])[CH3:2]

참가 물질

3

반응물 1

HCID 128327651-Isopropyl-5-dichloroacetylaminomethylisoquinoline

생성물 1

HCID 128327661-Isopropyl-5-aminomethylisoquinoline수율 67.6%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

Twenty grams of 1-isopropyl-5-dichloroacetylaminomethylisoquinoline was dissolved in 100 ml of conc. hydrochloric acid. The solution was heated with stirring for 1 hour. The reaction mixture was concentrated, made weakly alkaline with an aqueous solution of sodium hydroxide, and extracted with benzene to afford 8.7 g of 1-isopropyl-5-aminomethylisoquinoline as an oil.

후처리

  1. temperatureThe solution was heated
  2. concentrationThe reaction mixture was concentrated
  3. extractionextracted with benzene

출처 및 근거

ORD 기록
ord-5694418be72e4cd8b47309ea5529f185
출처 데이터셋
uspto-grants-1982_06
특허 번호
US04337256

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