HCID 53755671, 화합물 → 3-(4-Chlorobenzoyl)-2-methylbenzene hexanoic acid

HRID 1157008노트

반응식

HRID 1157008 반응식
[H][H].[Cl:3][C:4]1[CH:26]=[CH:25][C:7]([C:8]([C:10]2[C:11]([CH3:24])=[C:12]([CH2:16][CH:17]=[CH:18][CH2:19][CH2:20][C:21]([OH:23])=[O:22])[CH:13]=[CH:14][CH:15]=2)=[O:9])=[CH:6][CH:5]=1>CO.[Ni]>[Cl:3][C:4]1[CH:5]=[CH:6][C:7]([C:8]([C:10]2[C:11]([CH3:24])=[C:12]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]([OH:23])=[O:22])[CH:13]=[CH:14][CH:15]=2)=[O:9])=[CH:25][CH:26]=1

참가 물질

5

반응물 2

HCID 53755671HCID 53755671, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 205344893-(4-Chlorobenzoyl)-2-methylbenzene hexanoic acid

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

Hydrogen was passed through a mixture of 16.27 g of 6-[3'-(4-chlorobenzoyl)-2'-methyl-phenyl]-hex-4-enoic acid in 80 ml of methanol and 16.3 g of Raney nickel and then the catalyst was filtered off. The methoanol was distilled from the filtrate and the residue was taken up in methylene chloride. The solution was dried, treated with activated carbon, filtered and evaporated to dryness to obtain, after crystallization from a 1-1 isorpopyl ether-petroleum ether mixture, 11.15 g of 6-[3'-(4-chlorobenzoyl)-2'-methyl-phenyl]-hexanoic acid melting at 82° C.

후처리

  1. filtrationthe catalyst was filtered off
  2. distillationThe methoanol was distilled from the filtrate
  3. customThe solution was dried
  4. additiontreated with activated carbon
  5. filtrationfiltered
  6. customevaporated to dryness
  7. customto obtain
  8. customafter crystallization from a 1-1 isorpopyl ether-petroleum ether mixture, 11.15 g of 6-[3'-(4-chlorobenzoyl)-2'-methyl-phenyl]-hexanoic acid melting at 82° C.

출처 및 근거

ORD 기록
ord-077a4a3960cf4468a58083d413d2bbbf
출처 데이터셋
uspto-grants-1982_06
특허 번호
US04337353

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