1-(Benzyloxy)-2-bromo-4-nitrobenzene → 4-Benzyloxy-3-bromophenylamine

HRID 1157155노트

반응식

HRID 1157155 반응식
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][C:10]=1[Br:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)C.O.Cl.[Fe]>[NH2:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[C:10]([Br:18])[CH:11]=1

참가 물질

6

반응물 1

HCID 220178401-(Benzyloxy)-2-bromo-4-nitrobenzene

생성물 1

HCID 220177374-Benzyloxy-3-bromophenylamine

시약·촉매·용매 4

HCID 313Hydrochloric Acid촉매HCID 23925Iron촉매HCID 702Ethanol용매HCID 962Water용매

실험 절차

To a solution of 1-benzyloxy-2-bromo-4-nitrobenzene (50 mg, 0.16 mmol) in ethanol (5 mL) and H2O (0.5 mL) was added iron (134 mg, 2.43 mmol) and one drop of concentrated HCl. The mixture was refluxed for 6 hrs and filtrated. The filtrate was diluted with ethyl acetate, washed with saturated sodium bicarbonated solution, dried over sodium sulfate and concentrated to afford crude 4-amino-1-benzyloxy-2-bromobenzene.

후처리

  1. temperatureThe mixture was refluxed for 6 hrs
  2. filtrationfiltrated
  3. additionThe filtrate was diluted with ethyl acetate
  4. washwashed with saturated sodium bicarbonated solution
  5. dry with materialdried over sodium sulfate
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-de2d28f143f94fd79d2e308c49dda941
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07807672B2

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