Morpholine → 4-(5-Bromopyrazin-2-yl)morpholine

HRID 1157311노트

반응식

HRID 1157311 반응식
[H-].[Na+].[NH:3]1[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1.[Br:9][C:10]1[C:15](Br)=[N:14][CH:13]=[CH:12][N:11]=1>C1COCC1>[Br:9][C:10]1[N:11]=[CH:12][C:13]([N:3]2[CH2:8][CH2:7][O:6][CH2:5][CH2:4]2)=[N:14][CH:15]=1

참가 물질

5

반응물 3

HCID 8083MorpholineHCID 24758Sodium hydrideHCID 138675722,3-Dibromopyrazine

생성물 1

HCID 457874804-(5-Bromopyrazin-2-yl)morpholine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To sodium hydride (0.20 g) taken in THF (15 ml), morpholine (0.735 ml) was added under nitrogen, at 0° C. The reaction mixture stirred for about 15 minutes, then 2,3-dibromopyrazine (2 g) dissolved in dry THF (15 ml) was added. The reaction mixture was allowed to stir at reflux conditions for overnight. The reaction mixture was quenched with water (5 ml), and volatiles were removed under vacuum. The resulting crude mass was purified by column chromatography to afford pure 4-(5-bromopyrazin-2-yl)morpholine.

후처리

  1. additionwas added
  2. stirringto stir
  3. temperatureat reflux conditions for overnight
  4. customThe reaction mixture was quenched with water (5 ml), and volatiles
  5. customwere removed under vacuum
  6. customThe resulting crude mass was purified by column chromatography

출처 및 근거

ORD 기록
ord-77b2b6796dd84061bf00eab192fe7cbb
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07807671B2

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