Hydrochloric Acid → HCID 68521714, 화합물

HRID 1157448노트

반응식

HRID 1157448 반응식
C[O:2][C:3](=[O:24])[C:4]1[CH:9]=[C:8]([O:10][CH2:11][CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[CH:7]=[CH:6][C:5]=1[NH:20]C(=O)C.[ClH:25]>>[ClH:25].[ClH:25].[NH2:20][C:5]1[CH:6]=[CH:7][C:8]([O:10][CH2:11][CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)=[CH:9][C:4]=1[C:3]([OH:24])=[O:2]

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 685239932-Acetylamino-5-(3-piperidin-1-ylpropoxy)benzoic acid methyl ester

생성물 1

HCID 68521714HCID 68521714, 화합물수율 100%

실험 절차

2-Acetylamino-5-(3-piperidin-1-ylpropoxy)benzoic acid methyl ester (1.34 g, 4.0 mmol) was treated with 6N HCl (aq.) (20 mL) and heated at reflux temperature for 8 h. The mixture was then cooled and concentrated in vacuo to afford 2-amino-5-(3-piperidin-1-ylpropoxy)benzoic acid dihydrochloride (1.4 g, 4.0 mmol, 100%).

후처리

  1. temperatureheated
  2. temperatureat reflux temperature for 8 h
  3. temperatureThe mixture was then cooled
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-aa917166df5442a0a708e41c046e9ad6
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07807686B2

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