Methyl iodide → Ethyl 2-(pyridin-4-yl)propanoate

HRID 1158061노트

반응식

HRID 1158061 반응식
[Li]N([Si](C)(C)C)[Si](C)(C)C.[N:11]1[CH:16]=[CH:15][C:14]([CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:13][CH:12]=1.[CH3:23]I>C1COCC1>[N:11]1[CH:16]=[CH:15][C:14]([CH:17]([CH3:23])[C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:13][CH:12]=1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 736321Ethyl pyridine-4-acetateHCID 178418261HCID 178418261, 화합물

생성물 1

HCID 11651240Ethyl 2-(pyridin-4-yl)propanoate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of LiN(TMS)2 (Aldrich, 1.0 M solution in THF, 30 mL, 30 mmol) in THF (30 mL) was added ethyl 4-pyridylacetate (Aldrich, 4.7 mL, 30 mmol)) at 0° C. Methyl iodide (Aldrich, 2.4 mL, 38 mmol) was added 30 min later. After 1 h, the reaction mixture was concentrated in vacuo. The crude product was purified by silica gel chromatography. Mass Spec. m/z+ion 180 (M+1).

후처리

  1. concentrationthe reaction mixture was concentrated in vacuo
  2. customThe crude product was purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-7b348aade2a44a4897ead385b0bf66b6
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07807700B2

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