Fluorobenzene → 4-Fluoro-4'-(phenylethynyl)benzophenone

HRID 1158547

반응식

HRID 1158547 반응식
Br[C:2]1[CH:16]=[CH:15][C:5]([C:6]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.F[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.Br[C:25]1C=CC(C(Cl)=O)=C[CH:26]=1.[Cl-].[Al+3].[Cl-].[Cl-]>>[F:14][C:11]1[CH:12]=[CH:13][C:8]([C:6]([C:5]2[CH:15]=[CH:16][C:2]([C:25]#[C:26][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:3][CH:4]=2)=[O:7])=[CH:9][CH:10]=1

참가 물질

5

반응물 4

HCID 10008FluorobenzeneHCID 685154-Bromobenzoyl chlorideHCID 74951(4-Bromophenyl)(4-fluorophenyl)methanoneHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 40956574-Fluoro-4'-(phenylethynyl)benzophenone

실험 절차

4-bromo-4′-fluorobenzophenone: fluorobenzene (6.89 g, 71.7 mmol), 4-bromobenzoyl chloride (7.86 g, 35.8 mmol), and aluminum chloride (4.78 g, 35.8 mmol) were combined and stirred for 24 h at room temperature. The resulting mixture was poured over ice, and then filtered. The solid was dissolved in hot ethanol, treated with decolorizing charcoal, and filtered; white crystals of the title compound formed upon cooling of the ethanol solution and were isolated by filtration.

후처리

  1. additionThe resulting mixture was poured over ice
  2. filtrationfiltered
  3. dissolutionThe solid was dissolved in hot ethanol
  4. additiontreated with decolorizing charcoal
  5. filtrationfiltered

출처 및 근거

ORD 기록
ord-791b65999ffc4c9597c9fd8e1a11e6c2
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07811499B2

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