Hydrochloric Acid → 7-Tert-butyl-chroman-4-ol

HRID 1158784

반응식

HRID 1158784 반응식
[C:1]([C:5]1[CH:6]=[C:7]([CH:17]=[CH:18][CH:19]=1)[O:8][CH2:9][CH2:10][CH:11]1[O:16]CCCO1)([CH3:4])([CH3:3])[CH3:2].Cl>O1CCCC1.C(OCC)C>[C:1]([C:5]1[CH:6]=[C:7]2[C:17]([CH:11]([OH:16])[CH2:10][CH2:9][O:8]2)=[CH:18][CH:19]=1)([CH3:2])([CH3:3])[CH3:4]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 595485522-[2-(3-Tert-butyl-phenoxy)-ethyl]-[1,3]dioxane

생성물 1

HCID 595485267-Tert-butyl-chroman-4-ol

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 8028Tetrahydrofuran용매

실험 절차

The intermediate from step A was dissolved in 20 ml tetrahydrofuran. Concentrated hydrochloric acid (20 mL) was added, and the reaction mixture was stirred at ambient temperature for 4 hours, diluted with diethyl ether and washed with water. The isolated organic layer was dried with magnesium sulfate, filtered and the solvent removed under reduced pressure to give 2.87 g of crude 7-tert-butyl-chroman-4-ol which was used without further purification.

후처리

  1. washwashed with water
  2. dry with materialThe isolated organic layer was dried with magnesium sulfate
  3. filtrationfiltered
  4. customthe solvent removed under reduced pressure

출처 및 근거

ORD 기록
ord-d25c8a5b32e84a68a77b3e7aee1f0cba
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07812019B2

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