Hydrochloric Acid → (3R)-4-nitrosothiomorpholine-3-carboxylic acid

HRID 1158869

반응식

HRID 1158869 반응식
[N:1]([O-:3])=O.[Na+].Cl.[NH:6]1[CH2:11][CH2:10][S:9][CH2:8][C@H:7]1[C:12]([OH:14])=[O:13]>>[N:1]([N:6]1[CH2:11][CH2:10][S:9][CH2:8][C@H:7]1[C:12]([OH:14])=[O:13])=[O:3]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 1152541(R)-thiomorpholine-3-carboxylic acidHCID 23668193Sodium Nitrite

생성물 1

HCID 58700709(3R)-4-nitrosothiomorpholine-3-carboxylic acid

실험 절차

NaNO2 (3.14 g) was added to the 1 mol/L HCl (33.7 mL) solution of (3R)-thiomorpholine-3-carboxylic acid (4.96 g) under a nitrogen atmosphere at 0° C. and stirred for 0.5 h. The solution was extracted with CHCl3 (5 times) and the organic layer was washed with brine. The mixture was dried over MgSO4 and concentrated under reduced pressure to afford crude (3R)-4-nitrosothiomorpholine-3-carboxylic acid as pale yellow crystals.

후처리

  1. extractionThe solution was extracted with CHCl3 (5 times)
  2. washthe organic layer was washed with brine
  3. dry with materialThe mixture was dried over MgSO4
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-a204133015fc4a3c8e0fe9fe93a67ce5
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07812014B2

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