Bromomethylcyclopropane → Indole

반응식

F[C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[CH:4][CH:3]=1.C1(CBr)CC1.CN1C(SC2SC(N)=NC=2)=NN=N1>>[NH:8]1[C:9]2[C:5](=[CH:4][CH:3]=[CH:2][CH:10]=2)[CH:6]=[CH:7]1

참가 물질

반응물 3

HCID 81503Bromomethylcyclopropane

HCID 3512786-Fluoroindole

HCID 157291862-amino-5-(1-methyl-1H-tetrazol-5-ylthio)thiazole

생성물 1

HCID 798Indole

실험 절차

6-fluoroindole, R5X=cyclopropyl-methylbromide; NH2A=5-(1-methyl-1-H-tetrazol-5-ylsulfanyl)-thiazole-2-ylamine

출처 및 근거

ORD 기록: ord-2b8cee4dd51a4a08a1bdde551e38762e
출처 데이터셋: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07812043B2

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