2-Chloro-1-(2-methoxyethoxy)-4-nitrobenzene → 3-Chloro-4-(2-methoxyethoxy)aniline

HRID 1159929노트

반응식

HRID 1159929 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[O:11][CH2:12][CH2:13][O:14][CH3:15]>CCOC(C)=O.C(O)C.[Pt]>[Cl:1][C:2]1[CH:7]=[C:6]([CH:5]=[CH:4][C:3]=1[O:11][CH2:12][CH2:13][O:14][CH3:15])[NH2:8]

참가 물질

5

반응물 1

HCID 595137122-Chloro-1-(2-methoxyethoxy)-4-nitrobenzene

생성물 1

HCID 64857493-Chloro-4-(2-methoxyethoxy)aniline수율 97.6%

시약·촉매·용매 3

HCID 23939Platinum촉매HCID 702Ethanol용매HCID 8857Ethyl Acetate용매

실험 절차

2-Chloro-1-{[2-(methyloxy)ethyl]oxy}-4-nitrobenzene (1.0 g) was dissolved in a 1:1 solution of EtOAc and ethanol (30 mL). Pt/C (0.15 g of 10% by weight) was added and the resulting mixture was placed under 50 psi of H2 for 16 h. The reaction was then filtered through celite and the resulting organics were concentrated in vacuo to obtain 0.85 g of the compound. 1H NMR (300 MHz, DMSO-d6): δ 6.88 (d, 1H), 6.66 (m, 1H), 6.50 (m, 1H), 4.00 (m, 2H), 3.63 (m, 2H), 3.33 (s, 3H).

후처리

  1. filtrationThe reaction was then filtered through celite
  2. concentrationthe resulting organics were concentrated in vacuo

출처 및 근거

ORD 기록
ord-35b927438199451f9f1267fdd9271980
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07812022B2

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