Hydrochloric Acid → 3-amino-3-benzyldihydrofuran-2(3H)-one

HRID 1160180노트

반응식

HRID 1160180 반응식
[CH2:1]([C:8]1([N:14]=C(C2C=CC=CC=2)C2C=CC=CC=2)[CH2:12][CH2:11][O:10][C:9]1=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>CO.C1COCC1>[NH2:14][C:8]1([CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH2:12][CH2:11][O:10][C:9]1=[O:13]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 866323393-benzyl-3-[(diphenylmethylene)amino]dihydrofuran-2(3H)-one

생성물 1

HCID 140831243-amino-3-benzyldihydrofuran-2(3H)-one

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 3-benzyl-3-[(diphenylmethylene)amino]dihydrofuran-2(3H)-one (5.67 g, 15.95 mmol) in MeOH (50 mL) and THF (50 mL) was added 6N HCl (5.3 mL, 32 mmol). After 5 min stirring at RT, the reaction mixture was concentrated in vacuo, diluted with water and benzophenone was extracted with diethyl ether (3×). The aqueous layer was basified to pH 10 with 6N NaOH, extracted with DCM (×2), dried over sodium sulfate and concentrated in vacuo to give 3-amino-3-benzyldihydrofuran-2(3H)-one as a colorless oil, which was carried as is in the next step.

후처리

  1. concentrationthe reaction mixture was concentrated in vacuo
  2. additiondiluted with water and benzophenone
  3. extractionwas extracted with diethyl ether (3×)
  4. extractionextracted with DCM (×2)
  5. dry with materialdried over sodium sulfate
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-2b6f8d85bea242548bed64faff1ae22a
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07816378B2

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