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Hydrochloric Acid → 3-[4-(2'-Butoxy-5'-methyl-biphenyl-4-ylmethoxy)-phenyl]-3-(4-fluorophenyl)-propionic acid ethyl ester

HRID 1160312
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반응식

HRID 1160312 반응식
[CH2:1]([O:3][C:4](=[O:21])[CH2:5][CH:6]([C:14]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=1)[C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1)[CH3:2].Br[CH2:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]2[CH:35]=[C:34]([CH3:36])[CH:33]=[CH:32][C:31]=2[O:37][CH2:38][CH2:39][CH2:40][CH3:41])=[CH:26][CH:25]=1.C(=O)([O-])[O-].[Cs+].[Cs+].Cl>CN(C=O)C.O>[CH2:1]([O:3][C:4](=[O:21])[CH2:5][CH:6]([C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:23][C:24]2[CH:25]=[CH:26][C:27]([C:30]3[CH:35]=[C:34]([CH3:36])[CH:33]=[CH:32][C:31]=3[O:37][CH2:38][CH2:39][CH2:40][CH3:41])=[CH:28][CH:29]=2)=[CH:9][CH:8]=1)[C:14]1[CH:15]=[CH:16][C:17]([F:20])=[CH:18][CH:19]=1)[CH3:2]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 10796Cesium carbonateHCID 578357253-(4-Fluorophenyl)-3-(4-hydroxyphenyl)-propionic acid ethyl esterHCID 598551134'-Bromomethyl-2-butoxy-5-methyl-biphenyl

생성물 1

HCID 591326263-[4-(2'-Butoxy-5'-methyl-biphenyl-4-ylmethoxy)-phenyl]-3-(4-fluorophenyl)-propionic acid ethyl ester수율 79.1%

시약·촉매·용매

2
HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

A mixture of 45.2 (48 mg, 0.166 mmol), 4′-Bromomethyl-2-butoxy-5-methyl-biphenyl (67 mg, 0.2 mmol) and cesium carbonate (81 mg, 0.25 mmol) in DMF (2 mL) was stirred at room temperature overnight. The reaction mixture was diluted with water, acidified with dilute HCl, extracted into ethyl acetate, washed with water and dried over magnesium sulfate. The residue obtained after concentration was flash chromatographed on silica gel to obtain 45.3 (71 mg).

후처리

  1. extractionextracted into ethyl acetate
  2. washwashed with water
  3. dry with materialdried over magnesium sulfate
  4. customThe residue obtained
  5. concentrationafter concentration
  6. customchromatographed on silica gel

출처 및 근거

ORD 기록
ord-00acf399afec48c1b94855edb0a2540d
출처 데이터셋
uspto-grants-2010_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07816367B2

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