Sodium borohydride → 2-Chloro-4-{[(3S)-1-(2-hydroxyethyl)-5-oxo-3-pyrrolidinyl][(2-methylphenyl)methyl]amino}benzonitrile
반응식
[Cl:1][C:2]1[CH:9]=[C:8]([N:10]([CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[CH3:27])[C@H:11]2[CH2:15][C:14](=[O:16])[N:13]([CH2:17][CH:18]=[O:19])[CH2:12]2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[BH4-].[Na+]>C1COCC1>[Cl:1][C:2]1[CH:9]=[C:8]([N:10]([C@H:11]2[CH2:15][C:14](=[O:16])[N:13]([CH2:17][CH2:18][OH:19])[CH2:12]2)[CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[CH3:27])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]참가 물질
4
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생성물 1
시약·촉매·용매 1
실험 절차
2-Chloro-4-{[(2-methylphenyl)methyl][(3S)-5-oxo-1-(2-oxoethyl)-3-pyrrolidinyl]amino}benzonitrile from the previous step was dissolved in THF, and NaBH4 (1.2 eq) was added. After stirring at room temperature for 2 h, the reaction mixture was quenched with H2O and extracted three times with ethyl acetate (5 mL). The organics were dried over anhydrous MgSO4 and concentrated to give the titled compound as white solid (3.5 g, 33% for two steps). LC-MS (ES) m/e 384.6 (M+H)+.