Ethyl bromoacetate → 2-Trifluromethyl-4-nitrophenoxyacetic acid ethyl ester

HRID 1160427

반응식

HRID 1160427 반응식
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:4]=1[OH:12].Br[CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18].C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[CH2:20]([O:19][C:17](=[O:18])[CH2:16][O:12][C:4]1[CH:5]=[CH:6][C:7]([N+:9]([O-:11])=[O:10])=[CH:8][C:3]=1[C:2]([F:13])([F:14])[F:1])[CH3:21]

참가 물질

5

반응물 3

HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 3014014Phenol, 4-nitro-2-(trifluoromethyl)-

생성물 1

HCID 192616082-Trifluromethyl-4-nitrophenoxyacetic acid ethyl ester수율 95%

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

A mixture of 2-trifluoromethyl-4-nitrophenol (73.4 g, 0.354 mol), ethyl bromoacetate (65.2 g, 0.39 mol), potassium carbonate (58.7 g, 0.425 mol) and 2-butanone (400 mL) was refluxed under stirring for 10 h. The solid was filtered off, the filtrate was evaporated and the residue was fractionated yielding 97.8 g (95%) of 2-trifluromethyl-4-nitrophenoxyacetic acid ethyl ester, b.p. 126° C./40 Pa.

후처리

  1. temperaturewas refluxed
  2. filtrationThe solid was filtered off
  3. customthe filtrate was evaporated

출처 및 근거

ORD 기록
ord-79e7ca7fc78b4de0abd00959d8e0b2bc
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07816385B2

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