Dimethylformamide dimethyl acetal → (Z)-N-(2-adamantyl)-2-(cyclopentanecarbonyl)-3-dimethylamino-prop-2-enamide

HRID 1160549노트

반응식

HRID 1160549 반응식
CO[CH:3](OC)[N:4]([CH3:6])[CH3:5].[CH:9]12[CH2:18][CH:13]3[CH2:14][CH:15]([CH2:17][CH:11]([CH2:12]3)[CH:10]1[NH:19][C:20](=[O:29])[CH2:21][C:22]([CH:24]1[CH2:28][CH2:27][CH2:26][CH2:25]1)=[O:23])[CH2:16]2>O1CCOCC1>[CH:9]12[CH2:16][CH:15]3[CH2:14][CH:13]([CH2:12][CH:11]([CH2:17]3)[CH:10]1[NH:19][C:20](=[O:29])/[C:21](/[C:22]([CH:24]1[CH2:28][CH2:27][CH2:26][CH2:25]1)=[O:23])=[CH:3]\[N:4]([CH3:5])[CH3:6])[CH2:18]2

참가 물질

4

반응물 2

HCID 78373Dimethylformamide dimethyl acetalHCID 59516089N-(2-adamantyl)-3-cyclopentyl-3-oxo-propanamide

생성물 1

HCID 59516145(Z)-N-(2-adamantyl)-2-(cyclopentanecarbonyl)-3-dimethylamino-prop-2-enamide수율 99.5%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

반응 조건

온도
100 °C

실험 절차

N,N-Dimethylformamide dimethyl acetal (0.587 mL, 4.42 mmol) was added to N-(2-adamantyl)-3-cyclopentyl-3-oxo-propanamide (Intermediate#72), (1.023 g, 3.53 mmol) in 1,4-dioxane (25 mL). The resulting solution was stirred at 100° C. for 2 hours. The resulting mixture was evaporated to dryness to afford (Z)—N-(2-adamantyl)-2-(cyclopentanecarbonyl)-3-dimethylamino-prop-2-enamide (1.210 g, 99%).

후처리

  1. customThe resulting mixture was evaporated to dryness

출처 및 근거

ORD 기록
ord-0f1c04eddc3f4657acab568fcc3e52ea
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07816391B2

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