Hydrochloric Acid → Methyl 4-hydrazinyl-2-methoxybenzoate hydrochloride

HRID 1160557노트

반응식

HRID 1160557 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:13](C(OC(C)(C)C)=O)[NH2:14])[CH:6]=[CH:7][C:8]=1[C:9]([O:11][CH3:12])=[O:10].[ClH:22]>O1CCOCC1>[ClH:22].[NH:13]([C:5]1[CH:6]=[CH:7][C:8]([C:9]([O:11][CH3:12])=[O:10])=[C:3]([O:2][CH3:1])[CH:4]=1)[NH2:14]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 57437909Tert-butyl 1-(3-methoxy-4-(methoxycarbonyl)phenyl)hydrazinecarboxylate

생성물 1

HCID 57437908Methyl 4-hydrazinyl-2-methoxybenzoate hydrochloride수율 92%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

반응 조건

온도
20 °C

실험 절차

tert-butyl 1-(3-methoxy-4-(methoxycarbonyl)phenyl)hydrazinecarboxylate (Intermediate#112) (4.86 g, 16.40 mmol) was added to a 4M solution of hydrogen chloride (61.5 mL, 246 mmol) in dioxane. The resulting solution was stirred at 20° C. for 5 hours. The reaction mixture was evaporated to dryness and the crude residue was triturated with Et2O to give a solid which was collected by filtration and dried under vacuum to give methyl 4-hydrazinyl-2-methoxybenzoate hydrochloride (3.50 g, 92%) as a pale green solid.

후처리

  1. customThe reaction mixture was evaporated to dryness
  2. customthe crude residue was triturated with Et2O
  3. customto give a solid which
  4. filtrationwas collected by filtration
  5. customdried under vacuum

출처 및 근거

ORD 기록
ord-fc60d8007e0142bba9efc65e1aa7b7f1
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07816391B2

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