Sodium Hydroxide → 4-[1-(4'-Isopropyl-2,6-dimethyl-biphenyl-4-yloxy)-2-methyl-propyl]-benzoic acid

HRID 1160928노트

반응식

HRID 1160928 반응식
C[O:2][C:3](=[O:32])[C:4]1[CH:9]=[CH:8][C:7]([CH:10]([O:14][C:15]2[CH:20]=[C:19]([CH3:21])[C:18]([C:22]3[CH:27]=[CH:26][C:25]([CH:28]([CH3:30])[CH3:29])=[CH:24][CH:23]=3)=[C:17]([CH3:31])[CH:16]=2)[CH:11]([CH3:13])[CH3:12])=[CH:6][CH:5]=1.[OH-].[Na+]>CO>[CH:28]([C:25]1[CH:24]=[CH:23][C:22]([C:18]2[C:19]([CH3:21])=[CH:20][C:15]([O:14][CH:10]([C:7]3[CH:8]=[CH:9][C:4]([C:3]([OH:32])=[O:2])=[CH:5][CH:6]=3)[CH:11]([CH3:13])[CH3:12])=[CH:16][C:17]=2[CH3:31])=[CH:27][CH:26]=1)([CH3:29])[CH3:30]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 671535504-[1-(4'-Isopropyl-2,6-dimethyl-biphenyl-4-yloxy)-2-methyl-propyl]-benzoic acid methyl ester

생성물 1

HCID 671535774-[1-(4'-Isopropyl-2,6-dimethyl-biphenyl-4-yloxy)-2-methyl-propyl]-benzoic acid수율 91.2%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To the solution of isomer 1 of 4-[1-(4′-isopropyl-2,6-dimethyl-biphenyl-4-yloxy)-2-methyl-propyl]-benzoic acid methyl ester (510 mg) in methanol (10 mL) is added sodium hydroxide (5 N aqueous, 2 mL) and stirred for 4 h. The reaction mixture is concentrated and acidified by 5 N HCl (2 mL), extracted with ethyl acetate. Combined organic layers are washed with water and brine, dried over sodium sulfate. Concentration gives the title compound (450 mg) as a white solid.

후처리

  1. concentrationThe reaction mixture is concentrated
  2. extractionextracted with ethyl acetate
  3. washCombined organic layers are washed with water and brine
  4. dry with materialdried over sodium sulfate
  5. concentrationConcentration

출처 및 근거

ORD 기록
ord-f980f747b4d94962b1158431822a1914
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07816557B2

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