(-)-(4-(1-Acetoxy-ethyl)phenyl)-5-decyloxypyrimidine → 2-(4-(1-Hydroxyethyl)phenyl)-5-decyloxypyrimidine

HRID 1161

반응식

HRID 1161 반응식
C([O:4][CH:5]([C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])=[CH:15][N:14]=2)=[CH:9][CH:8]=1)[CH3:6])(=O)C>CO.[OH-].[Na+]>[OH:4][CH:5]([C:7]1[CH:8]=[CH:9][C:10]([C:13]2[N:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])=[CH:15][N:14]=2)=[CH:11][CH:12]=1)[CH3:6]

참가 물질

4

반응물 1

HCID 19694897(-)-(4-(1-Acetoxy-ethyl)phenyl)-5-decyloxypyrimidine

생성물 1

HCID 214682802-(4-(1-Hydroxyethyl)phenyl)-5-decyloxypyrimidine

시약·촉매·용매 2

HCID 887Methanol용매HCID 14798Sodium Hydroxide용매

반응 조건

온도
30 °C

실험 절차

4 g of the above product (-)-(4-(1-acetoxyethyl) phenyl)-5-decyloxypyrimidine was dissolved in a mixture of 50 ml of methanol and 10 ml of a 20% sodium hydroxide solution, stirred at 30° C. for 2 hours and hydrolyzed, and the resulting reaction solution was extracted by adding 200 ml of water and 200 ml of toluene, followed by liquid separation. The obtained organic layer was dried over anhydrous magnesium sulfate and cleared of solvent in vacuo to yield 3.5 g of (-)-(4-(1-hydroxyethyl) phenyl)-5-decyloxypyrimidine as a white solid.

후처리

  1. customhydrolyzed, and the resulting reaction solution
  2. extractionwas extracted
  3. additionby adding 200 ml of water and 200 ml of toluene
  4. customfollowed by liquid separation
  5. dry with materialThe obtained organic layer was dried over anhydrous magnesium sulfate

출처 및 근거

ORD 기록
ord-01a269bda00c4ee495d089d890ae2b6c
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05723610

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