Hydrochloric Acid → 3-(3-hydroxymethyl-phenyl)-4H-[1,2,4]oxadiazol-5-one
반응식
Cl.O1CCCCC1[O:8][CH2:9][C:10]1[CH:11]=[C:12]([C:16]2[NH:20][C:19](=[O:21])[O:18][N:17]=2)[CH:13]=[CH:14][CH:15]=1>O1CCCC1.[Cl-].[Na+].O>[OH:8][CH2:9][C:10]1[CH:11]=[C:12]([C:16]2[NH:20][C:19](=[O:21])[O:18][N:17]=2)[CH:13]=[CH:14][CH:15]=1참가 물질
5
실험 절차
Add 10% hydrochloric acid (100 ml) to a solution of 3-[3-(tetrahydro-pyran-2-yloxymethyl)-phenyl]-4H-[1,2,4]oxadiazol-5-one (4.50 g, 16.3 mmol) in tetrahydrofuran (0.1M) and stir. After 18 hours, pour reaction into brine and extract with ethyl acetate. Combine the organic layers, dry with sodium sulfate, filter and concentrate under reduced pressure to yield the title product as a white solid (3.10 g, 99%): 1H NMR (DMSO-d6) δ 4.57 (s, 2H), 7.55 (m, 2H), 7.67 (dt, 1H), 7.81 (m, 1H), 12.95 (bs, 1H).
후처리
- additionpour
- extractionextract with ethyl acetate
- dry with materialdry with sodium sulfate
- filtrationfilter
- concentrationconcentrate under reduced pressure
출처 및 근거
- ORD 기록
- ord-970a43ed42224c14a97dfa9effb062df
- 출처 데이터셋
- uspto-grants-2010_10
- 특허 번호
- US07816523B2
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