Pyridine → 2-(6-Chloro-5-nitro-1-oxoisoquinolin-2(1H)-yl)ethyl acetate

HRID 1161294노트

반응식

[Cl:1][C:2]1[C:3]([N+:16]([O-:18])=[O:17])=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:7]([CH2:13][CH2:14][OH:15])[CH:6]=[CH:5]2.[C:19](OC(=O)C)(=[O:21])[CH3:20].N1C=CC=CC=1.C(Cl)Cl>>[C:19]([O:15][CH2:14][CH2:13][N:7]1[CH:6]=[CH:5][C:4]2[C:9](=[CH:10][CH:11]=[C:2]([Cl:1])[C:3]=2[N+:16]([O-:18])=[O:17])[C:8]1=[O:12])(=[O:21])[CH3:20]

참가 물질

반응물 4

HCID 1049Pyridine

HCID 6344Dichloromethane

HCID 7918Acetic Anhydride

HCID 595156676-Chloro-2-(2-hydroxyethyl)-5-nitroisoquinolin-1(2H)-one

생성물 1

HCID 595159062-(6-Chloro-5-nitro-1-oxoisoquinolin-2(1H)-yl)ethyl acetate

실험 절차

A round bottom flask was charged with 6-chloro-2-(2-hydroxyethyl)-5-nitroisoquinolin-1(2H)-one (400.0 mg, 0.00149 mol), acetic anhydride (0.21 mL, 0.0022 mol), pyridine (0.18 mL, 0.0022 mol) and methylene chloride (20 mL, 0.2 mol) and the reaction stirred at room temperature over night. The solvent was removed to obtain the product as a yellow solid. MS m/z=311.3 (M+H).

후처리

customThe solvent was removed

출처 및 근거

ORD 기록: ord-0b310bc247884c7a889b07c16a31da32
출처 데이터셋: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07816371B2

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