Hydrazine hydrate (1:1) → 3-Amino-5-bromo-1H-indazole
반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5](F)=[C:6]([CH:9]=1)[C:7]#[N:8].O.[NH2:12][NH2:13]>O>[NH2:8][C:7]1[C:6]2[C:5](=[CH:4][CH:3]=[C:2]([Br:1])[CH:9]=2)[NH:13][N:12]=1참가 물질
4
실험 절차
A mixture of 5-bromo-2-fluorobenzonitrile (5.00 g, 25 mmol) and hydrazine hydrate (10 mL) was heated at reflux for two hours and then it was allowed to stand at room temperature for two days. The reaction was treated with water (50 mL) and the solids were collected by filtration to give 3-Amino-5-bromo-indazole as a white solid (4.82 g, 91%): mp 165-175° C.; MS [M+H]+ 212, 214.
후처리
- temperaturewas heated
- temperatureat reflux for two hours
- filtrationthe solids were collected by filtration
출처 및 근거
- ORD 기록
- ord-48f441ac35d34c3f877041965344fe1b
- 출처 데이터셋
- uspto-grants-2010_10
- 특허 번호
- US07820670B2
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