4-(4-Isopropyl-phenyl)-thiazol-2-ylamine → HCID 59520223, 화합물
반응식
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]([NH2:15])[S:13][CH:14]=2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[C:16]([O:20][C:21](=[O:27])[CH2:22][S:23](Cl)(=[O:25])=[O:24])([CH3:19])([CH3:18])[CH3:17]>CN(C1C=CN=CC=1)C>[C:16]([O:20][C:21](=[O:27])[CH2:22][S:23](=[O:24])(=[O:25])[NH:15][C:12]1[S:13][CH:14]=[C:10]([C:7]2[CH:6]=[CH:5][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:9][CH:8]=2)[N:11]=1)([CH3:19])([CH3:17])[CH3:18]참가 물질
4
실험 절차
4-(4-Isopropyl-phenyl)-thiazol-2-ylamine, chlorosulfonyl-acetic acid tert-butyl ester, DMAP (10 mol %) were combined using general procedure C (method 2) to afford [4-(4-Isopropyl-phenyl)-thiazol-2-ylsulfamoyl]-acetic acid tert-butyl ester. LCMS m/z: 398 (M+1)+; 1H NMR (CDCl3, 400 MHz): δ 1.27 (d, 6H); 1.44 (s, 9H); 2.95 (m, 1H); 4.06 (s, 2H); 6.48 (s, 1H); 7.32 (d, 2H); 7.39 (d, 2H); 10.5 (brs, 1H).