Oxalyl chloride → 4-(4-Isopropyl-phenyl)-thiazole-2-carbonyl chloride

HRID 1162602노트

반응식

HRID 1162602 반응식
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]([C:15]([OH:17])=O)[S:13][CH:14]=2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].C(Cl)(=O)C([Cl:21])=O>C(Cl)(Cl)Cl>[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]([C:15]([Cl:21])=[O:17])[S:13][CH:14]=2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 207501802-Thiazolecarboxylic acid, 4-[4-(1-methylethyl)phenyl]-

생성물 1

HCID 860798104-(4-Isopropyl-phenyl)-thiazole-2-carbonyl chloride

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

4-(4-Isopropyl-phenyl)-thiazole-2-carbonyl chloride was prepared by refluxing a mixture of 4-(4-Isopropyl-phenyl)-thiazole-2-carboxylic acid (50 mg) and oxalyl chloride (300 μl) in chloroform (5 mL). After 3 h, the volatiles were evaporated and the residue was dried under high vacuum to provide the acid chloride (50 mg).

후처리

  1. temperatureby refluxing
  2. customthe volatiles were evaporated
  3. customthe residue was dried under high vacuum

출처 및 근거

ORD 기록
ord-52b0ee15dd494030b44d3c5b9a598395
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07820704B2

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